New paper in Biomedicine & Pharmacotherapy

21 02 2025

Check out our new review in Biomedicine & Pharmacotherapy, co-authored by Prof. Grzegorz Litwinienko, in collaboration with the University of Łódź, Gdańsk University of Technology, the Military Institute of Medicine – National Research Institute (Poland), and the University of Valencia (Spain).

Nanotechnology meets radiobiology: Fullerenols and Metallofullerenols as nano-shields in radiotherapy

Biomedicine & Pharmacotherapy, 2025, 184, 117915, DOI: 10.1016/j.biopha.2025.117915

Despite advances in radioprotective measures, clinical use remains limited due to toxicity and low efficacy. In radiotherapy, conventional agents may also reduce treatment effectiveness. Fullerenols (FulOHs) and metallofullerenols (Me@FulOHs) offer a promising alternative with superior antioxidant properties and reduced pro-oxidative risks under optimized conditions. Me@FulOHs also serve as theranostic tools, enhancing PET/MRI imaging for early cancer detection. Their dual role in protection and diagnosis supports safer, more precise radiotherapy. This review explores their potential, alongside ionizing radiation effects, classifications, and countermeasures.