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Paweł Przybylski, MSc

Paweł was born in Chełm, in 1995. He received his BSc and MSc degree at the University of Warsaw, Faculty of Chemistry. He defended with Suma Cum Laude his MSc thesis entitled “High-pressure mediated enantioselective addition of diethyl malonate to β,β-disubstituted aromatic enones” under the supervision of dr hab. Piotr Kwiatkowski in 2019. In the same year he joined our research group. His interests combine research from the frontiers of physical chemistry, organic chemistry, radical chemistry, chemical kinetics with cell biology. Some of the substances he studies have cytotoxic activity, which is beneficial in anticancer therapies, but antioxidant activity is also important to his project in research and therapies for cell aging and prevention of mitochondrial peroxidation. In his current PhD project, under the supervision of prof. Grzegorz Litwinienko. The project subject is Physico-chemical principles of antioxidant action: from solvent effect and mechanistic studies to interfacial phenomena in biologically relevant systems.

ORCID E-mail

Publications

Antioxidant Activity of Bilirubin in Micellar and Liposomal Systems Is pH-Dependent
P. Przybylski, M. Żebrowski, W. Witkowski, M. Cybularczyk-Cecotka, G. Litwinienko*
Antioxidants2024, 13, 4, 426; DOI: 10.3390/antiox13040426

Mutation Status and Glucose Availability Affect the Response to Mitochondria-Targeted Quercetin Derivative in Breast Cancer Cells
P. Przybylski, A. Lewińska, I. Rzeszutek, D. Błoniarz, A. Moskal, G. Betlej, A. Deręgowska, M. Cybularczyk-Cecotka, T. Szmatoła, G. Litwinienko*, M. Wnuk*
Cancers, 2023, 15, 23, 5614, DOI: 10.3390/cancers15235614

Concentration-dependent HAT/ET mechanism of the reaction of phenols with 2,2-diphenyl-1-picrylhydrazyl (dpph˙) in methanol
P. Przybylski, A. Konopko, P. Łętowski, K. Jodko-Piórecka, G. Litwinienko*
RSC Advances2022, 12, 13, 8131–8136, DOI: 10.1039/D2RA01033J

Antiradical Activity of Dopamine, L-DOPA, Adrenaline, and Noradrenaline in Water/Methanol and in Liposomal Systems
K. Jodko-Piórecka*, B. Sikora, M. Kluzek, P. Przybylski, G. Litwinienko*
Journal of Organic Chemistry2022, 87, 3, 1791–1804, DOI: 10.1021/acs.joc.1c02308

Senolysis-Based Elimination of Chemotherapy-Induced Senescent Breast Cancer Cells by Quercetin Derivative with Blocked Hydroxy Groups
A. Lewińska*, P. Przybylski, J. Adamczyk-Grochala, D. Błoniarz, G. Litwinienko, M. Wnuk*
Cancers2022, 14, 3, 605, DOI: 10.3390/cancers14030605

Antioxidant activity of two edible isothiocyanates: Sulforaphane and erucin is due to their thermal decomposition to sulfenic acids and methylsulfinyl radicals
J. Cedrowski, K. Dąbrowa, P. Przybylski, A. Krogul-Sobczak, G. Litwinienko*
Food Chemistry2021, 353, 129213, DOI: 10.1016/j.foodchem.2021.129213