New paper in Nanotoxicology
27 01 2025
Category: Publications
Check out a new study, co-authored by Dr. Piotr Piotrowski and Prof. Grzegorz Litwinienko in collaboration with the University of Rzeszów and the Łukasiewicz Research Network–Institute of Non-Ferrous Metals, explores the anticancer potential of urotropine-modified iron oxide nanoparticles (URO@Fe3O4 NPs). The research demonstrates that URO@Fe3O4 NPs induce oxidative stress and impair the unfolded protein response (UPR) in breast cancer cells, particularly under glucose-deprived conditions, leading to genetic instability and cell death. This comprehensive analysis across 40 breast cancer cell lines highlights the nanoparticles’ selective anticancer effects and potential as a novel therapeutic strategy for breast cancer treatment.
Read more about this research:
Evaluation of anticancer activity of urotropine surface modified iron oxide nanoparticles using a panel of forty breast cancer cell lines
J. Adamczyk-Grochala, M. Wnuk, B. Oklejewicz, K. Klimczak, D. Błoniarz, A. Deręgowska, I. Rzeszutek, P. Stec, A. Ciuraszkiewicz, M. Kądziołka-Gaweł, D. Łukowiec, P. Piotrowski, G. Litwinienko, A. Radoń*, A. Lewińska*