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Dr Katarzyna Sęktas

| Dr Katarzyna Sęktas

Katarzyna in 2006 started her PhD studies at the Faculty of Chemistry, University of Santiago de Compostela (Spain), under the supervision of Prof. Antonio Mouriño. After a one-year stay in Spain, she started her PhD studies at the University of Warsaw in the Laboratory of Stereocontrolled Organic Synthesis (PSSO), under the supervision of Prof. Rafał Sicinski. Continuing her collaboration with Prof. Mouriño, after passing the required examinations at the University of Santiago de Compostela in 2008, she was awarded the Diploma of Doctoral Studies (Diploma de Estudios Avanzados: DEA, equivalent to Master of Research). Later, in 2012, Katarzyna defended his PhD thesis entitled: “Synthesis of 6-substituted vitamin D3 analogues” under the supervision of Prof. Rafał Sicinski and Prof. Antonio Mouriño. Since 2007, she has completed a total of nine research internships (over 30 months in total) at the Department of Biochemistry of the University of Wisconsin-Madison (USA), in the laboratory of Prof. Hector F. DeLuca, the Department of Chemistry of the University of Santiago de Compostela (Spain), in the laboratory of Prof. Antonio Mouriño, and at the Institute of Experimental Botany of AS CR and Palacký University in Olomouc (Czech Republic), in the laboratory of Prof. Miroslav Strnad. After completing her PhD, she continued her work in the PSSO where she focused, among other projects, on the synthesis of biologically active compounds. In 2024 she moved to the Laboratory of Technology of Organic Functional Materials to work with Dr Eng. Wojciech Danowski.

ORCID E-mail

Publications

Cholesterol-based photo-switchable mesogenic dimers. Strongly bent molecules versus an intercalated structure
A. Zep*, K. Pruszkowska, Ł. Dobrzycki, K. Sektas, P. Szałański, P.H. Marek, M.K. Cyrański, R.R. Sicinski
CrystEngComm, 2019, 21, 2779-2789, DOI: 10.1039/C9CE00013E

Synthesis of 19-norcalcitriol analogs with elongated side chain
P. Brzeminski, A. Fabisiak, K. Sektas, K. Berkowska b, E. Marcinkowska, R.R. Sicinski*
Journal of Steroid Biochemistry & Molecular Biology, 2018, 177, 231–234, DOI: 10.1016/j.jsbmb.2017.08.008

Design, synthesis and biological properties of seco-d-ring modified 1α,25-dihydroxyvitamin D3 analogues
M. Szybinski, K. Sektas, R.R. Sicinski*, Lori A. Plum, J. Frelek, H.F. DeLuca*
Journal of Steroid Biochemistry & Molecular Biology, 2017, 173, 57–63, DOI: 10.1016/j.jsbmb.2017.03.006

D-seco-Vitamin D analogs having reversed configurations at C-13 and C-14: Synthesis, docking studies and biological evaluation
M. Szybinski, K. Sokolowska, R.R. Sicinski*, L.A. Plum, H.F. DeLuca*
Journal of Steroid Biochemistry & Molecular Biology, 2017, 173, 57–63, DOI: 10.1016/j.jsbmb.2016.08.009

Synthesis and Biological Activity of Two C-7 Methyl Analogues of Vitamin D
K. Sokolowska, D. Carballa, S. Seoane, R. Pérez-Fernández, A. Mouriño*, R.R. Sicinski*†
J. Org. Chem., 2015, 80, 1, 165–173, DOI: 10.1021/jo502243r

Unusual Course of the Reaction of Allyl Phosphine Oxides with the Grundmann Ketone
K. Sokolowska, R.R. Sicinski*
Synthetic Communications, 2014, 44(20), 2943–2954, DOI: 10.1080/00397911.2014.909491

Synthesis of novel vitamin D3 analog with an additional ring annulated to A and seco-B rings
K. Sokolowska, R.R. Sicinski*
Steroids, 2014, 87, 67–75, DOI: 10.1016/j.steroids.2014.05.016

Synthesis and biological evaluation of novel 6-substituted analogs of 1α,25-dihydroxy-19-norvitamin D3
K. Sokolowska, R.R. Sicinski, A. Mouriño, L.A. Plum, H.F. DeLuca*
Journal of Steroid Biochemistry & Molecular Biology, 2013, 136, 30–33, DOI: 10.1016/j.jsbmb.2012.10.016

An efficient synthesis of 1α,25-dihydroxy-20-epi-vitamin D3
R. Fraga, B. López-Pérez, K. Sokolowska, A. Guini, T. Regueira, S. Díaz, A. Mouriño, M.A. Maestro*
Journal of Steroid Biochemistry & Molecular Biology, 2013, 136, 14–16, DOI: 10.1016/j.jsbmb.2013.01.010

Synthesis and biological evaluation of 6-methyl analog of 1α,25-dihydroxyvitamin D3
K. Sokolowska, A. Mouriño, R.R. Sicinski, R. Sigüeiro, L.A. Plum, H.F. DeLuca*
Journal of Steroid Biochemistry & Molecular Biology, 2010, 121, 29–33, DOI: 10.1016/j.jsbmb.2010.02.008

Crystal structure, electronic properties and cytotoxic activity of palladium chloride complexes with monosubstituted pyridines
A. Glebocka, K. Sokolowska, R.R. Sicinski, L.A. Plum, H.F. DeLuca*
J. Med. Chem., 2009, 52, 11, 3496–3504, DOI: 10.1021/jm9001583

Patents

6-Methylvitamin D3 analogs and their uses
H.F. DeLuca, A. Głębocka, K. Sokołowska, R.R. Siciński, L.A. Plum, M. Clagett-Dame
U.S. Pat. No. 8.178.517 (15/05/2012)

19-Nor-vitamin D analogs with 1,2-dihydrofuran ring
H.F. DeLuca, A. Głębocka, K. Sokołowska, R.R. Siciński, L.A. Plum, M. Clagett-Dame
U.S. Pat. No. 7.879.829 (01/02/2011)

6-Methylvitamin D3 analogs and their uses
H.F. DeLuca, L.A. Plum, M. Clagett-Dame, K. Sokołowska, A. Mouriuo, , R.R. Siciński
WO 2011 41.599A2 (07/04/2011)

19-Nor-vitamin D analogs with 3,2-dihydrofuran ring
H.F. DeLuca, A. Głębocka, K. Sokołowska, R.R. Siciński, L.A. Plum, M. Clagett-Dame
U.S. Pat. No. 7.648.974 (09/01/2010)

19-Nor-vitamin D analogs with 1,2-dihydrofuran ring
H.F. DeLuca, A. Głębocka, K. Sokołowska, R.R. Siciński, L.A. Plum, M. Clagett-Dame
WO 2010 6.123A2 (14/01/2010)

19-Nor-vitamin D analogs with 3,2-dihydrofuran ring
H.F. DeLuca, A. Głębocka, K. Sokołowska, R.R. Siciński, L.A. Plum, M. Clagett-Dame
WO 2010 6.121A2 (14/01/2010)